Artigo
Algumas palavras sobre o assunto: como estudar o que as palavras não descrevem?
Este capítulo discute desde os aspectos econômico-sociais da dor, os mecanismos e mediadores envolvidos, as bases anatômicas, teorias, diferenças na percepção dolorosa, a importância em sentir dor e os problemas da sua cronificação, as drogas utilizadas e as perspectivas para o seu tratamento, métodos utilizados para avaliar a dor em humanos e a influência de diferenças genéticas.
Referências:
1. R. Melzack, P.D. Wall, "Pain mechanisms: A new theory," Science, 150:171-9, 1965.
2. R. Melzack, P.D. Wall, "On nature of cutaneous sensory mechanisms," Brain, 85:331, 1962.
3. M. Galea, "Vale professor Patrick Wall," Australian J Physiother, 47:303, 2001.
4. P.T. Mäntyselkä, "Chronic pain and poor self-rated health," JAMA, 290:2435-42, 2003.
5. A.C. Gough et al, "Identification of the primary gene defect at the cytochrome P450 CYP2D locus," Nature, 347:773-6, 1990.
6. JK. Zubieta et al., "COMT val158met genotype affects Ì-opioid neurotransmitter responses to a pain stressor," Science, 299:1240-3, 2003.
7. M.P. Jankowski et al., "Developmentally-regulated transcription factor Sox 11 is activated in adult mice after peripheral inflammation and axotomy," Society for Neuroscience, Program No. 289.13, 2004.
8. J.A.M. Coull et al., "Trans-synaptic shift in anion gradient in spinal lamina 1 neurons as a mechanism of neuropathic pain," Nature, 424:938-42, 2003.
Referências:
1. R. Melzack, P.D. Wall, "Pain mechanisms: A new theory," Science, 150:171-9, 1965.
2. R. Melzack, P.D. Wall, "On nature of cutaneous sensory mechanisms," Brain, 85:331, 1962.
3. M. Galea, "Vale professor Patrick Wall," Australian J Physiother, 47:303, 2001.
4. P.T. Mäntyselkä, "Chronic pain and poor self-rated health," JAMA, 290:2435-42, 2003.
5. A.C. Gough et al, "Identification of the primary gene defect at the cytochrome P450 CYP2D locus," Nature, 347:773-6, 1990.
6. JK. Zubieta et al., "COMT val158met genotype affects Ì-opioid neurotransmitter responses to a pain stressor," Science, 299:1240-3, 2003.
7. M.P. Jankowski et al., "Developmentally-regulated transcription factor Sox 11 is activated in adult mice after peripheral inflammation and axotomy," Society for Neuroscience, Program No. 289.13, 2004.
8. J.A.M. Coull et al., "Trans-synaptic shift in anion gradient in spinal lamina 1 neurons as a mechanism of neuropathic pain," Nature, 424:938-42, 2003.