Artigo
Portais para a dor patológica: transdução de sinal e o sistema imune -participação das MAP quinases na dor
Jill U. Adams revisa a participação das proteínas quinases ativadas por mitógenos (MAP quinases) na hipersensibilidade nociceptiva. O enfoque é dado à proteína p38 (um tipo de MAP quinase), a qual é ativada pelo Fator de Necrose Tumoral (TNF), induzindo a síntese e liberação de citocinas.
Referências:
1. S-.X. Jin et al., "p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain," J Neurosci, 23: 4017-22, 2003.
2. M. Schäfers et al., "Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons," J Neurosci, 23: 2517-21, 2003.
3. V. Raghavendra et al., "Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy," J Pharmacol Exp Ther, 306: 624-30, 2003.
4. E.D. Milligan et al., "Spinal glia and proinflammatory cytokines mediated mirror-image neuropathic pain in rats," J Neurosci, 23: 1026-40, 2003.
Referências:
1. S-.X. Jin et al., "p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain," J Neurosci, 23: 4017-22, 2003.
2. M. Schäfers et al., "Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons," J Neurosci, 23: 2517-21, 2003.
3. V. Raghavendra et al., "Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy," J Pharmacol Exp Ther, 306: 624-30, 2003.
4. E.D. Milligan et al., "Spinal glia and proinflammatory cytokines mediated mirror-image neuropathic pain in rats," J Neurosci, 23: 1026-40, 2003.